(Journal Article): Genes Mediating Environment Interactions in Type 1 Diabetes
 
Biros E, Jordan MA, Baxter AG (Comparative Genomics Centre, Molecular Sciences Building 21, James Cook University, Townsville QLD 4811, Australia, alan.baxter(at)jcu.edu.au )
 
IN: Rev Diabetic Stud 2005; 2(4):192-207
Impact Factor(s) of Rev Diabetic Stud: 0.125 (2006)

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ABSTRACT: The relative risk of type 1 (autoimmune) diabetes mellitus for a sibling of an affected patient is fifteen times that of the general population, indicating a strong genetic contribution to the disease. Yet, the incidence of diabetes in most Western communities has doubled every fifteen years since the Second World War - a rate of increase that can only possibly be explained by a major etiological effect of environment. Here, the authors provide a selective review of risk factors identified to date. Recent reports of linkage of type 1 diabetes to genes encoding pathogen pattern recognition molecules, such as toll-like receptors, are discussed, providing a testable hypothesis regarding a mechanism by which genetic and environmental influences on disease progress are integrated.

TYPE OF PUBLICATION: Review

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