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Oxidative Stress/Glucose Toxicity
(Journal Article): Involvement of Oxidative Stress and the JNK Pathway in Glucose Toxicity
Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Matsuoka T
IN:
Rev Diabetic Stud
2004; 1(4):165-174
Impact Factor(s) of Rev Diabetic Stud: 0.125 (2006)
ABSTRACT:
The hallmark of type 2 diabetes is pancreatic beta-cell dysfunction and insulin resistance. Normal beta-cells can compensate for insulin resistance by increasing insulin secretion,...
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(Journal Article): Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
Evans JL, Goldfine ID, Maddux BA, Grodsky GM
IN:
Diabetes
2003; 52:1-8
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
ABSTRACT:
In both type 1 and type 2 diabetes, diabetic complications in target organs arise from chronic elevations of glucose. The pathogenic effect of high glucose, possibly in concert wit...
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