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(Journal Article): Will C-Peptide Substitution Make a Difference in Combating Complications in Insulin-Deficient Diabetes?
Sima AAF (Departments of Pathology and Neurology, Wayne State University, 540 E. Canfield Avenue, Detroit, MI 48201, USA,
asima(at)med.wayne.edu
)
IN:
Rev Diabetic Stud
2004; 1(2):55-57
Impact Factor(s) of Rev Diabetic Stud: 0.125 (2006)
Fulltext:
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ABSTRACT: Not available.
TYPE OF PUBLICATION: Editorial
REFERENCES:
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- Sima AAF (ed). Physiological and pathophysiological significance of C-peptide actions. Exp Diab Res 2004. 5:1-96.
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- Grunberger G, Qiang X, Li Z-G, Mathews ST, Sbriessa D, Shisheva A, Sima AAF. Molecular basis for the insulinomimetic effects of C-peptide. Diabetologia 2001. 44:1247-1257.
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- Greene DA, Lattimer SA and Sima AAF. Sorbitol, phosphoinositides and sodium-potassium ATPase in the pathogenesis of diabetic complications. N Engl J Med 1987. 316:599-606.
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- Sima AAF. New insights into the metabolic and molecular basis for diabetic neuropathy. Cell Mol Life Sci 2003. 60:2445-2464.
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- Forst T, De La Tour DD, Kunt T, Pfutzner A, Goitom K, Pohlmann T, Schneider S, Johansson BL, Wahren J, Lo-big M, et al. Effects of proinsulin C-peptide on nitric oxide, microvascular blood flow and erythrocyte Na+/K+-ATPase activity in diabetes mellitus type 1. Clin Sci 2000. 98:283-290.
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- Li Z-G, Zhang W, Sima AAF. C-peptide enhances insulin-mediated cell growth and protection against high glucose induced apoptosis in SH-SY5Y cells. Diab Metab Res Rev 2003. 19:375-385.
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- Pierson CR, Zhang W, Sima AAF. Proinsulin C-peptide replacement in type 1 diabetic BB/Wor-rats prevents deficits in nerve fiber regeneration. J Neuropath Exp Neurology 2003. 62:765-779.
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- Sima AAF, Zhang W, Li Z-G, Murakawa Y, Pierson CR. Molecular alterations underlie nodal and paranodal degenera-tion in type 1 diabetic neuropathy and are prevented by C-peptide. Diabetes 2004. 53:1556-1563.
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- Johansson B-L, Linde B, Wahren J. Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type 1 (insulin-dependent) diabetic patients. Diabetologia 1992. 35:1151-1158.
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- Forst T, Kunt T, Pohlmann T, Goitom K, Engelbach M, Beyer J, Pfutzner A. Biological activity of C-peptide on the skin microcirculation in patients with insulin-dependent diabetes mellitus. J Clin Invest 1998. 101:2036-2041.
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- Johansson B-L, Borg K, Fernquist-Forbes E, Kernell A, Odergren T, Wahren J. Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type 1 diabetes mellitus. Diabetes Med 2000. 17:181-189.
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- Ekberg K, Brismar T, Johansson BL, Jonsson B, Lindström P, Wahren J. Amelioration of sensory nerve dysfunction by C-peptide in patients with type 1 diabetes. Diabetes 2003. 52:536-541.
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- The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993. 329:977-986.
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- Zhang W, Yorek M, Pierson CR, Murakawa Y, Breidenbach A, Sima AAF. Human C-peptide dose dependently prevents early neuropathy in the BB/Wor-rat. Internatl J Exp Diab Res 2001. 2(3):187-194.
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- Vague P, Coste TC, Jannot MF, Raccah D, Tsimaratos M. C-peptide, Na+/K+-ATPase and diabetes. Exp Diab Res 2001. 24:1187-1191.
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- Li Z-G, Zhang W, Sima AAF. C-peptide prevents hippocampal apoptosis in type 1 diabetes. Internatl J Exp Diab Res 2002. 3:241-246.
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- Sima AAF, Kamiya H. The changing view of diabetic neuropathy. Science Med (in press).
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- Li H, Xu L, Dunbar JC, Dhabuwala CB, Sima AAF. Effects of C-peptide on expression of endothelial NOS (eNOS) and inducible NOS (iNOS) in human cavernosal smooth muscle cell. J Urol (in press).
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- Stevens MJ, Zhang W, Li F, Sima AAF. C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB/Wor-rats. Am J Physiol (in press).
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