(Journal Article): Vitamin D receptors and compensatory tissue growth in spontaneously diabetic BB rats.
 
Stone LA, Weaver VM, Bruns ME, Christakos S, Welsh J (Department of Biochemistry, School of Medicine, University of Ottawa, Ont., Canada.)
 
IN: Ann Nutr Metab 1991; 35:196-202
Impact Factor(s) of Ann Nutr Metab: 1.067 (2004), 1.01 (2001)

ABSTRACT: Untreated diabetic (BB) rats exhibited compensatory intestinal growth which was associated with hyperplasia and was accompanied by an increase in unoccupied vitamin D receptors. Although vitamin D receptors were increased, low circulating 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] prevented amplification of the action of 1,25(OH)2D3, as evidenced by reductions in calbindin D-9K and alkaline phosphatase activity in the BB rat intestine compared to control. In the kidney, a lesser degree of compensatory growth was observed which was not associated with hyperplasia, and no significant effect of diabetes on vitamin D receptors or calbindin D-28K was observed. These studies suggest tissue-specific changes in 1,25(OH)2D3 metabolism during spontaneous diabetes which may be related to the hyperplasia which occurs during compensatory tissue growth.

TYPE OF PUBLICATION: Original article

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• Thongboonkerd V, Zheng S, McLeish KR, Epstein PN, Klein JB. Proteomic Identification and Immunolocalization of Increased Renal Calbindin-D28k Expression in OVE26 Diabetic Mice. Rev Diabetic Stud 2005. 2: 19-26.
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