(Journal Article): Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.
 
Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP
 
IN: J Neurosci 1997; 17:4212-4222
Impact Factor(s) of J Neurosci: 7.907 (2004), 8.306 (2003), 8.178 (2001)

ABSTRACT: Most autosomal dominant inherited forms of early onset Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS-1) gene on chromosome 14. PS-1 is an integral membra... Click HERE for details