Antidiabetic, antioxidant and antihyperlipidemic status of heliotropium zeylanicum extract on streptozotocin-induced diabetes in rats

(Journal Article): Antidiabetic, antioxidant and antihyperlipidemic status of heliotropium zeylanicum extract on streptozotocin-induced diabetes in rats

Murugesh K, Yeligar V, Dash DK, Sengupta P, Maiti BC, Maity TK. (Department of Pharmaceutical Technology, Division of Pharmaceutical Chemistry, Jadavpur University; India, sarugesh@yahoo.com )

IN: Biol Pharm Bull 2006; 29(11):2202-2205
Impact Factor(s) of Biol Pharm Bull: 1.392 (2004), 1.124 (2003), 1.038 (2002), 0.82 (2001)

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ABSTRACT: The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration of (MEHZ) 150 and 300 mg/kg/d for 14 d significantly decreased the blood glucose level and considerably increased the body weight, food intake, and liquid intake of diabetic-induced rats. MEHZ significantly decreased thiobarbituric acid reactive substances and significantly increased reduced glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 14 d of treatment. The study also investigated the antihyperlipidemic potential of MEHZ. The results show that the active fraction of MEHZ is promising for development of a standardized phytomedicine for the treatment of diabetes mellitus.

TYPE OF PUBLICATION: Original article

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