(Journal Article): SOCS-1 protein prevents Janus Kinase/STAT-dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma.
Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B
IN:
J Biol Chem
2001; 276(28):25862–25870.-
Impact Factor(s) of J Biol Chem: 6.355 (2004), 6.482 (2003), 7.258 (2001)
ABSTRACT: In the pathogenesis of type I diabetes mellitus, activated leukocytes infiltrate pancreatic islets and induce beta cell dysfunction and destruction. Interferon (IFN)-gamma, tumor n... Click HERE for details