(Journal Article): Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stage.
 
Amrani A, Durant S, Throsby M, Coulaud J, Dardenne M, Homo-Delarche F (Centre National de la Recherche Scientifique Unite de Recherches Associee 1461-Universite Paris V, Hopital Necker, France.)
 
IN: Endocrinology 1998; 139:1115-1124
Impact Factor(s) of Endocrinology: 5.151 (2004), 5.063 (2003), 5.095 (2002), 4.971 (2001)

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ABSTRACT: Because few data were available on glucose homeostasis at the early prediabetic stage in the nonobese diabetic (NOD) mouse, we investigated glycemia, insulinemia, and pancreatic insulin content under basal conditions in both sexes of 4-, 6-, and 8-week-old fed NOD mice, compared with sex- and age-matched fed C57BL/6 mice. We also investigated glucose tolerance in both sexes of fasting 8-week-old NOD and C57BL/6 mice. The main results obtained under basal fed conditions, when comparing both strains, were lower glycemia and higher insulinemia in NOD females at all ages investigated and in NOD males (particularly at 6 weeks of age). Glucose tolerance tests showed that: 1) the blood glucose response to 1 g/kg i.p. glucose was less sustained in both sexes of 8-week-old NOD mice than in their control counterparts; 2) the blood insulin response to glucose (1 g/kg i.p.) appeared earlier in both sexes of NOD mice than in sex-matched C57BL/6 mice; 3) an unusual sexual dimorphism existed in NOD mice, compared with controls, with females secreting, in response to glucose, twice as much insulin as males; 4) dose-response studies (1-6 g/kg glucose) confirmed the lower increase in blood glucose levels in both sexes of NOD mice and their unusual sexual dimorphism in insulin secretion; and 5) glucose tolerance tests in 4- to 8-week-old NOD mice showed that although the sexual dimorphism in insulin secretion was not observed in 4-week-old mice, it was particularly striking at 6 weeks of age. Taken together, these results suggest that beta-cell hyperactivity exists in the NOD mouse at the early prediabetic stage, especially in NOD females.

TYPE OF PUBLICATION: Original article

Articles citing this article:

• Throsby M, Coulaud J, Durant S, Homo-Delarche F. Increased Transcriptional Preproinsulin II Beta-Cell Activity in Neonatal Nonobese Diabetic Mice: In Situ Hybridization Analysis. Rev Diabetic Stud 2005. 2: 75-83.
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