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(Journal Article): Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
Fajans SS, Bell GI, Polonsky KS (Department of Internal Medicine, University of Michigan Health System, Ann Arbor, USA,
sfajans@umich.edu
)
IN:
N Engl J Med
2001; 345(13):971-980
Impact Factor(s) of N Engl J Med: 44.016 (2005), 38.57 (2004), 34.833 (2003), 29.065 (2001)
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ABSTRACT: Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of inheritance, an onset usually before the age of 25 years and frequently in childhood or adolescence, and a primary defect in the function of the beta cells of the pancreas. MODY can result from mutations in any one of at least six different genes (Table 1). One of these genes encodes the glycolytic enzyme glucokinase (associated with MODY 2),3 and the other five encode transcription factors: hepatocyte nuclear factor (HNF) 4 (associated with MODY . . .
TYPE OF PUBLICATION: Review
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