Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion.

(Journal Article): Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion.

Dupraz P, Rinsch C, Pralong WF, Rolland E, Zufferey R, Trono D, Thorens B

IN: Gene Ther 1999; 6(6):1160–1169.-
Impact Factor(s) of Gene Ther: 4.977 (2004), 5.293 (2003), 5.616 (2002), 5.893 (2001)

ABSTRACT: betaTC-tet cells are conditionally immortalized pancreatic beta cells which can confer long-term correction of hyperglycemia when transplanted in syngeneic streptozocin diabetic mi... Click HERE for details