(Journal Article): Prospects for gene therapy of insulin-dependent diabetes mellitus.
 
Efrat S (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA.)
 
IN: Diabetologia 1998; 41(12):1401-1409
Impact Factor(s) of Diabetologia: 5.583 (2004), 5.689 (2003), 5.136 (2002), 6.299 (2001)

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ABSTRACT: The application of gene therapy to type I (insulin-dependent) diabetes mellitus awaits improvements in gene transfer technologies and the development of better tools for accurate diagnosis of pre-diabetic people. Identification of the most promising candidate genes for gene transfer requires further elucidation of the molecular events involved in beta-cell autoimmune destruction, islet ontogeny and differentiation, and beta-cell function. This review outlines a number of possible targets for gene therapy in type I diabetes, which could help prevent the autoimmune damage to islets, induce islet regeneration, and restore insulin production through engineering of self non-beta cells or beta-cell transplantation. It also evaluates their potential merits and drawbacks.

TYPE OF PUBLICATION: Review

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