(Journal Article): Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM
IN:
J Exp Med
2003; 198(12):1875-1886
Impact Factor(s) of J Exp Med: 14.588 (2004), 15.302 (2003), 15.34 (2001)
ABSTRACT: CD4+CD25+ regulatory T cells (Treg) are instrumental in the maintenance of immunological tolerance. One critical question is whether Treg can only be generated in the thymus or can... Click HERE for details
(Journal Article): Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.
Cobbold SP, Castejon R, Adams E, Zelenika D, Graca L, Humm S, Waldmann H
IN:
J Immunol
2004; 172:6003-6010
Impact Factor(s) of J Immunol: 6.486 (2004), 6.702 (2003), 7.065 (2001)
ABSTRACT: Transplantation tolerance can be induced in mice by grafting under the cover of nondepleting CD4 plus CD8 or CD154 mAbs. This tolerance is donor Ag specific and depends on a popula... Click HERE for details
(Journal Article): Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes.
Jaeckel E, von Boehmer H, Manns MP
IN:
Diabetes
2005; 54:306-310
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
ABSTRACT: CD4(+)CD25(+) T-cells can be used to interfere with spontaneous autoimmune diseases such as type 1 diabetes. However, their low frequency and often unknown specificity represent ma... Click HERE for details
|
||