Physiologic and immunologic hurdles to xenotransplantation.

(Journal Article): Physiologic and immunologic hurdles to xenotransplantation.

Samstein B, Platt JL (Department of Surgery, Mayo Clinic, Rochester, Minnesota, 55905, USA.)

IN: J Am Soc Nephrol 2001; 12(1):182-193
Impact Factor(s) of J Am Soc Nephrol: 6.644 (2004), 7.499 (2003), 6.337 (2001)

Fulltext: HTML PDF

ABSTRACT: The major problem in the field of renal transplantation is currently the shortage of available kidneys. However, the use of animals as a source of kidneys, i.e., xenotransplantation, is increasingly being viewed as a potential solution to this problem. One preeminent hurdle to xenotransplantation is the immune response of the recipient against the graft; other hurdles include the physiologic limitations of the transplant, infection, and ethical considerations. This review summarizes what is currently known regarding the obstacles to xenotransplantation and some potential solutions to those problems.

TYPE OF PUBLICATION: Review

Articles citing this article:

Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M. Insulin production by human embryonic stem cells. Diabetes 2001. 50: 1691-1697.
» Diabetes OD » Regeneration of Islets » Stem Cells » Embryonic Stem Cells » Journal Article

Respond on this Journal Article! Hint: Your Response should directly apply to *Physiologic and immunologic hurdles to xenotransplantation.. Please check, if this context applies best to your contribution. Otherwise click HERE* to change to the appropriate subject area. The actual subject area is Xenotransplantation.