C-peptide prevents hippocampal apoptosis in type 1 diabetes.

(Journal Article): C-peptide prevents hippocampal apoptosis in type 1 diabetes.

Li Z-G, Zhang W, Sima AAF

IN: Internatl J Exp Diabetes Res 2002; 3:241-246

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ABSTRACT: To explore mechanisms underlying central nervous system (CNS) complications in diabetes, we examined hippocampal neuronal apoptosis and loss, and the effect of C-peptide replacement in type 1 diabetic BB/W rats. Apoptosis was demonstrated after 8 months of diabetes, by DNA fragmentation, increased number of apoptotic cells, and an elevated ratio of Bax/Bcl-xL, accompanied by reduced neuronal density in the hippocampus. No apoptotic activity was detected and neuronal density was unchanged in 2-month diabetic hippocampus, whereas insulin-like growth factor (IGF) activities were impaired. In type 1 diabetic BB/W rats replaced with C-peptide, no TdT-mediated dUTP nick-end labeling (TUNEL)-positive cells were shown and DNA laddering was not evident in hippocampus at either 2 or 8 months. C-peptide administration prevented the preceding perturbation of IGF expression and reduced the elevated ratio of Bax/Bcl-xL. Our data suggest that type 1 diabetes causes a duration-dependent programmed cell death of the hippocampus, which is partially prevented by C-peptide.

TYPE OF PUBLICATION: Original article

Articles citing this article:

Sima AAF. Will C-Peptide Substitution Make a Difference in Combating Complications in Insulin-Deficient Diabetes? Rev Diabetic Stud 2004. 1: 55-57.
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