Neurogenic Inflammation in Acute Pancreatitis

(Journal Article): Neurogenic Inflammation in Acute Pancreatitis

Akhil Hegde, Madhav Bhatia (Department of Pharmacology, National University of Singapore. Singapore, mbhatia@nus.edu.sg )

IN: JOP. J Pancreas (Online) 2005; 06(5):417-421

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ABSTRACT: Acute pancreatitis is a clinical condition whose incidence has increased over the past few years. The exact mechanism of its development is not yet clear. Substance P, the proinflammatory neuropeptide, has a role in the initiation of neurogenic inflammation. Substance P and its receptor neurokinin-1 receptor (NK-1R) are involved in the development of local as well as systemic inflammation in acute pancreatitis. This editorial focuses on the role of substance P and its receptors in the development of acute pancreatitis.

TYPE OF PUBLICATION: Editorial

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