(Journal Article): Eighty years after insulin: parallels with modern islet transplantation.
 
Shapiro J (Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.)
 
IN: CMAJ 2002; 167(12):1398-1400
Impact Factor(s) of CMAJ: 4.783 (2003), 2.762 (2001)

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ABSTRACT: This year marks the 80th anniversary of the publication in CMAJ of the discovery of insulin by Frederick Banting and his colleagues at the University of Toronto. Some interesting historical parallels have emerged with the success of islet replacement therapy in diabetes. Up until just a few weeks ago, human islet cells were being prepared in the very same basement laboratories at the University of Alberta where the biochemist James Bertram Collip once worked on ethanol extraction of insulin, before he moved to Toronto and joined Banting's team.

TYPE OF PUBLICATION: Review

Articles citing this article:

• Emamaullee JA, Rajotte RV, Liston P, Korneluk RG, Lakey JR, Shapiro AM, Elliott JF. XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes. Diabetes 2005. 54: 2541-2548.
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