|
|
|
(Journal Article): Prospects for gene therapy of insulin-dependent diabetes mellitus.
Efrat S (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA.)
IN:
Diabetologia
1998; 41(12):1401-1409
Impact Factor(s) of Diabetologia: 5.583 (2004), 5.689 (2003), 5.136 (2002), 6.299 (2001)
Fulltext:
HTML
PDF
ABSTRACT: The application of gene therapy to type I (insulin-dependent) diabetes mellitus awaits improvements in gene transfer technologies and the development of better tools for accurate diagnosis of pre-diabetic people. Identification of the most promising candidate genes for gene transfer requires further elucidation of the molecular events involved in beta-cell autoimmune destruction, islet ontogeny and differentiation, and beta-cell function. This review outlines a number of possible targets for gene therapy in type I diabetes, which could help prevent the autoimmune damage to islets, induce islet regeneration, and restore insulin production through engineering of self non-beta cells or beta-cell transplantation. It also evaluates their potential merits and drawbacks.
TYPE OF PUBLICATION: Review
Articles citing this article:
|
Respond
on this Journal Article!
Hint: Your Response should directly apply to Prospects for gene therapy of insulin-dependent diabetes mellitus..
Please check, if this context applies best to your contribution. Otherwise click HERE to change to the appropriate
subject area. The actual subject area is Gene Therapy.
|
|
|
|
|
