Sub-Areas to Neural:
Neuronal gene expression
(1)
Neuronal Cell Apoptosis
(0)
Oxidative Stress
(0)
(Journal Article): Will C-Peptide Substitution Make a Difference in Combating Complications in Insulin-Deficient Diabetes?
Sima AAF
IN:
Rev Diabetic Stud
2004; 1(2):55-57
Impact Factor(s) of Rev Diabetic Stud: 0.125 (2006)
ABSTRACT: Not available. Click HERE for details
(Journal Article): Cervical necrotizing fasciitis with facial nerve paralysis
Al-Ammar A, Maqbool Mir S
IN:
J Laryngol Otol
2004; 118(7):573-575
Impact Factor(s) of J Laryngol Otol: 0.547 (2004), 0.528 (2003), 0.459 (2001)
ABSTRACT: Necrotizing fasciitis (NF) is a very aggressive infection with associated high mortality. Risk factors of acquiring this infection may include diabetes mellitus, surgery, trauma, a... Click HERE for details
(Journal Article): The proinsulin C-peptide - a multirole molecule.
Steiner DF
IN:
Exp Diab Res
2004; 5:7-14
(Journal Article): Physiological and pathophysiological significance of C-peptide actions.
Sima AAF (ed)
IN:
Exp Diabesity Res
2004; 5:1-96
(Journal Article): Role of C-peptide in human physiology.
Wahren J, Ekberg K, Johansson J, Henriksson M, Pramanik A, Johansson BL, Rigler R, Jornvall H
IN:
Am J Physiol Endocrinol Metab
2000; 278(5):E759-E768
Impact Factor(s) of Am J Physiol Endocrinol Metab: 4.431 (2004), 3.828 (2003), 3.324 (2001)
ABSTRACT: The C-peptide of proinsulin is important for the biosynthesis of insulin but has for a long time been considered to be biologically inert. Data now indicate that C-peptide in the n... Click HERE for details
(Journal Article): Molecular basis for the insulinomimetic effects of C-peptide.
Grunberger G, Qiang X, Li Z-G, Mathews ST, Sbriessa D, Shisheva A, Sima AAF
IN:
Diabetologia
2001; 44:1247-1257
Impact Factor(s) of Diabetologia: 5.583 (2004), 5.689 (2003), 5.136 (2002), 6.299 (2001)
(Journal Article): C-peptide induces a concentration-dependent dilatation of skeletal muscle arterioles only in the presence of insulin.
Jensen ME, Messina EJ
IN:
Am J Physiol
1999; 276:H1223-H1228
(Journal Article): Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein kinase dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats.
Kitamura T, Kimura K, Makondo K, Furuya DT, Suzuki M, Yoshida T, Saito M
IN:
Diabetologia
2003; 46:1698-1705
Impact Factor(s) of Diabetologia: 5.583 (2004), 5.689 (2003), 5.136 (2002), 6.299 (2001)
(Journal Article): Sorbitol, phosphoinositides and sodium-potassium ATPase in the pathogenesis of diabetic complications.
Greene DA, Lattimer SA and Sima AAF
IN:
N Engl J Med
1987; 316:599-606
Impact Factor(s) of N Engl J Med: 44.016 (2005), 38.57 (2004), 34.833 (2003), 29.065 (2001)
(Journal Article): Biochemistry and molecular cell biology of diabetic complications.
Brownlee M
IN:
Nature
2001; 414:813-820
Impact Factor(s) of Nature: 29.273 (2005), 32.182 (2004), 30.979 (2003), 30.432 (2002), 27.955 (2001)
(Journal Article): Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin-dependent diabetes, and demon-stration of axo-glial dysjunction in human diabetic neuropathy.
Sima AAF, Nathaniel V, Bril V, McEwen TAJ and Greene DA
IN:
J Clin Invest
1988; 81:349-364
Impact Factor(s) of J Clin Invest: 14.204 (2004), 14.307 (2003), 14.118 (2001)
(Journal Article): New insights into the metabolic and molecular basis for diabetic neuropathy.
Sima AAF
IN:
Cell Mol Life Sci
2003; 60:2445-2464
Impact Factor(s) of Cell Mol Life Sci: 4.995 (2003), 4.539 (2001)
(Journal Article): Effects of proinsulin C-peptide on nitric oxide, microvascular blood flow and erythrocyte Na+/K+-ATPase activity in diabetes mellitus type 1.
Forst T, De La Tour DD, Kunt T, Pfutzner A, Goitom K, Pohlmann T, Schneider S, Johansson BL, Wahren J, Lo-big M, et al
IN:
Clin Sci
2000; 98:283-290
(Journal Article): C-peptide enhances insulin-mediated cell growth and protection against high glucose induced apoptosis in SH-SY5Y cells.
Li Z-G, Zhang W, Sima AAF
IN:
Diabetes Metab Res Rev
2003; 19:375-385
Impact Factor(s) of Diabetes Metab Res Rev: 3.133 (2004), 1.907 (2001)
ABSTRACT: BACKGROUND: We have previously reported that C-peptide exerts preventive and therapeutic effects on diabetic neuropathy in type 1 diabetic BB/Wor-rats and that it prevents duration... Click HERE for details
(Journal Article): Proinsulin C-peptide replacement in type 1 diabetic BB/Wor-rats prevents deficits in nerve fiber regeneration.
Pierson CR, Zhang W, Sima AAF
IN:
J Neuropath Exp Neurology
2003; 62:765-779
(Journal Article): Molecular alterations underlie nodal and paranodal degenera-tion in type 1 diabetic neuropathy and are prevented by C-peptide.
Sima AAF, Zhang W, Li Z-G, Murakawa Y, Pierson CR
IN:
Diabetes
2004; 53:1556-1563
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
(Journal Article): Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type 1 (insulin-dependent) diabetic patients.
Johansson B-L, Linde B, Wahren J
IN:
Diabetologia
1992; 35:1151-1158
Impact Factor(s) of Diabetologia: 5.583 (2004), 5.689 (2003), 5.136 (2002), 6.299 (2001)
(Journal Article): Biological activity of C-peptide on the skin microcirculation in patients with insulin-dependent diabetes mellitus.
Forst T, Kunt T, Pohlmann T, Goitom K, Engelbach M, Beyer J, Pfutzner A
IN:
J Clin Invest
1998; 101:2036-2041
Impact Factor(s) of J Clin Invest: 14.204 (2004), 14.307 (2003), 14.118 (2001)
(Journal Article): Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type 1 diabetes mellitus.
Johansson B-L, Borg K, Fernquist-Forbes E, Kernell A, Odergren T, Wahren J
IN:
Diabetes Med
2000; 17:181-189
(Journal Article): Amelioration of sensory nerve dysfunction by C-peptide in patients with type 1 diabetes.
Ekberg K, Brismar T, Johansson BL, Jonsson B, Lindström P, Wahren J
IN:
Diabetes
2003; 52:536-541
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
(Journal Article): The effect of intensive treatment of diabetes on development and progression of long-term complications in insulin-dependent diabetes mellitus.
The Diabetes Control and Complications Trial Research Group
IN:
N Engl J Med
1993; 329:977-986
Impact Factor(s) of N Engl J Med: 44.016 (2005), 38.57 (2004), 34.833 (2003), 29.065 (2001)
(Journal Article): Human C-peptide dose dependently prevents early neuropathy in the BB/Wor-rat.
Zhang W, Yorek M, Pierson CR, Murakawa Y, Breidenbach A, Sima AAF
IN:
Internatl J Exp Diabetes Res
2001; 2(3):187-194
ABSTRACT: In order to explore the neuroprotective and cross-species activities of C-peptide on type 1 diabetic neuropathy, spontaneously diabetic BB/W-rats were given increasing doses of hum... Click HERE for details
(Journal Article): Effects of C-peptide on microvascular blood flow and blood hemorheology.
Forst T, Kunt T
IN:
Exp Diab Res
2004; 5:51-64
(Journal Article): C-peptide prevents hippocampal apoptosis in type 1 diabetes.
Li Z-G, Zhang W, Sima AAF
IN:
Internatl J Exp Diabetes Res
2002; 3:241-246
ABSTRACT: To explore mechanisms underlying central nervous system (CNS) complications in diabetes, we examined hippocampal neuronal apoptosis and loss, and the effect of C-peptide replacemen... Click HERE for details
(Journal Article): The changing view of diabetic neuropathy.
Sima AAF, Kamiya H
IN:
Science Med
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(Journal Article): Effects of C-peptide on expression of endothelial NOS (eNOS) and inducible NOS (iNOS) in human cavernosal smooth muscle cell.
Li H, Xu L, Dunbar JC, Dhabuwala CB, Sima AAF
IN:
J Urol
2004; 64(3):622-627
Impact Factor(s) of J Urol: 3.713 (2004), 3.297 (2003), 3.19 (2001)
ABSTRACT: OBJECTIVES: To investigate the role of C-peptide alone or in conjunction with insulin on the expression of nitric oxide synthase (NOS) in human corpus cavernosum smooth muscle cell... Click HERE for details
(Journal Article): C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB/Wor-rats.
Stevens MJ, Zhang W, Li F, Sima AAF
IN:
Am J Physiol
2004; 287(3):E497-505
ABSTRACT: Oxidative stress and neurovascular dysfunction have emerged as contributing factors to the development of experimental diabetic neuropathy (EDN) in streptozotocin-diabetic rodents.... Click HERE for details
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